在童年时代便消灭了糖果屋女巫的孤儿兄妹韩赛尔（杰瑞米·雷纳 Jeremy Renner 饰）与格蕾特（杰玛·阿特登 Gemma Arterton 饰），多年来成为邪恶女巫的最大克星。在帮助小镇奥古斯伯格寻找失踪的孩子以及隐藏女巫之时，兄妹二人发现三天后即将出现“血月”（月蚀），这对女巫们来说是无比重要和神圣的时刻。两兄妹迅速投入行动，而讨厌他们俩的警长也招来一伙人马追查女巫们的行踪。未过多久，女巫头目（法米克·詹森 Famke Janssen 饰）率领手下袭击小镇，与兄妹二人展开正面冲突。激战过后，格蕾特遭到重创，韩赛尔也随着女巫消失下落不明。 正邪的较量渐次升级，兄妹俩在这一过程中也渐渐知晓关于他们童年以及父母背后的秘密……The siblings Hansel and Gretel are left alone in the woods by their father and captured by a dark witch in a candy house. However they kill the witch and escape from the spot. Years later, the orphans have become famous witch hunters. When eleven children go missing in a small village, the Mayor summons Hansel and Gretel to rescue them, and they save the red haired Mina from the local sheriff who wants to burn her, accusing Mina of witchcraft. Soon they discover that the Blood Moon will approach in three days and the powerful dark witch Muriel is responsible for the abduction of children. She intends to use the children together with a secret ingredient in a Sabbath to make the coven of witches protected against the fire. Meanwhile Hansel and Gretel disclose secrets about their parents.
